Pathophysiological actions of neuropathy-related anti-ganglioside antibodies at the neuromuscular junction

Detection of Anti-Ganglioside Antibodies in Guillain-Barre Syndrome

The actions of tubocurarine at the frog neuromuscular junction.

1. The action of tubocurarine on voltage-clamped frog muscle end-plates has been re-examined by means (a) equilibrium dose-ratio measurements, (b) current fluctuation measurements and (c) voltage-jump relaxation measurements. 2. The equilibrium measurements can be interpreted as implying that tubocurarine has (a) a competitive blocking action, with a dissociation constant of 0.34 microM, which ...

Guillain-Barré syndrome anti-ganglioside-complex antibodies at mouse

Objectives: Anti-ganglioside antibodies are present in about half of the patients with Guillain-Barré syndrome (GBS). Recently it has been shown that a considerable proportion of these patients has serum antibodies against antigenic epitopes formed by a complex of two different gangliosides. However, direct experimental evidence for neuropathogenicity of this special category of antibodies is c...

Ganglioside reactive antibodies in the neuropathy associated with celiac disease.

We tested patients with celiac disease (CD) for the presence of serum anti-ganglioside antibodies. Six of twenty-seven patient sera were reactive against brain gangliosides by an agglutination immunoassay. Neurological examination in all six revealed the presence of distal sensory loss, consistent with the diagnosis of peripheral neuropathy. When tested by ELISA for antibodies to isolated GM1, ...

Anti-ganglioside antibodies in patients with rheumatoid arthritis complicated by peripheral neuropathy.

Gangliosides are a diverse class of glycolipids found in the plasma membrane of mammalian cells and are particularly abundant in cells of the nervous system. Serum antibodies to gangliosides have been detected in various neurological disorders with some evidence that they play a pathogenic role. In this study, we have investigated whether anti-ganglioside antibodies were elevated in a group of ...